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The wheels of an wheelchair are structurally in a closer position to the user's body than both arms are. Therefore, when the wheels are rolling, the side that touches a floor would roll and it has to touch the user's clothes or arms.
In general cases, a person who needs an wheelchair would be an old man or a patient. Since they have weaker immune systems than ordinary people do, the dirty side of the wheels could cause a superfluous additional disease or a secondary infection.
Korea Polytechnic Univ.
Siheung-si, Gyeonggi-do, South Korea